亚托皮炎和自身免疫性疾病的风险:系统性审查和元分析
Hongli Wang1,2, Min Chen1,2, Tengyue Wang1,2
1Innovative Research Center for Basic Medicine on Autoimmune Diseases, Ministry of Education, Hangzhou, Zhejiang, China.
亚托邦性皮肤炎 (AD) 与自身免疫性疾病有关. 这项对160多万患者的分析证实了显著的关联,强调了对这种慢性炎症性皮肤病的进一步研究的需要.
科学领域:
- 皮肤病学和免疫学
- 流行病学 流行病学
- 自免疫性疾病 自免疫性疾病
背景情况:
- 亚托皮炎 (AD) 是一种普遍存在的慢性炎症性皮肤疾病.
- 新出现的证据表明,阿尔茨海默病与自身免疫性疾病之间存在潜在的联系.
- 了解这种关联对于患者管理和研究至关重要.
研究的目的:
- 系统地审查和分析有关亚托皮性皮肤炎和自身免疫性疾病之间的关联的流行病学研究.
- 量化阿托皮性皮肤炎患者自身免疫性疾病的风险.
- 为了确定与AD相关的特定自身免疫疾病.
主要方法:
- 在PubMed,Cochrane图书馆和Embase数据库中进行全面的文献搜索,截至2024年5月24日.
- 包括队列,病例控制和横截面研究.
- 对26项涉及超过160万阿尔茨海默病患者和1500万对照患者的研究进行了元分析.
主要成果:
- 在阿托皮性皮炎和自身免疫性疾病之间发现了显著的关联 (HR 1.49,95% CI 1.31-1.70,P<0.001).
- 相关的自身免疫性疾病包括乳病,红斑狼,Sjogren综合征和类风湿性关节炎等.
- 这种联系在成人和儿童中都被观察到,女性患并发症的可能性更高.
结论:
- 亚托皮炎明显与一系列自身免疫性疾病有关.
- 女性似乎在患有AD时,自身免疫并发症的风险更高.
- 需要进一步的研究来充分阐明AD和自身免疫性疾病之间的复杂关系.
更多相关视频
06:47Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
Published on: September 27, 2017
09:32Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
Published on: September 26, 2019
相关概念视频
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
