怀孕期间自发性血皮质瘤的发生率,结果和管理:一项基于英国人口的研究
Ruth Tunn1, Rema Ramakrishnan1, Hilde Marie Engjom2
1National Perinatal Epidemiology Unit, University of Oxford, Old Road Campus, Headington, Oxford, OX3 7LF, UK.
NIHR open research
|June 27, 2025
概括
怀孕时自发性血 (SHiP) 是罕见但危险的,导致高比例的孕产妇和婴儿并发症. 这项研究调查了英国的SHiP发病率,诊断和结果.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 手术紧急情况 手术紧急情况
背景情况:
- 怀孕时自发性血 (SHiP) 被定义为怀孕期间腹腔内出血,不包括创伤或子宫破裂.
- SHiP是一种不常见的产科紧急情况,与早产,围产死亡率和孕产妇死亡率的重大风险有关.
研究的目的:
- 为了确定SHiP在英国的发病率.
- 研究SHiP的诊断方法,管理策略和临床结果.
主要方法:
- 一项为期两年的前性监测研究 (2016-2017年) 使用英国产科监测系统.
- 收集了来自英国顾问主导的产妇单位的匿名数据,这些数据是关于患有SHiP的妇女的.
主要成果:
- 确认了20例SHiP病例,发病率为每10万产妇中有1.3例.
- 常见的诊断包括胎盘断裂;常见的出血来源是动脉瘤和器官破裂/血瘤.
- 观察到高周围发病率 (16%的死胎,>80%的新生儿病房入院) 和母亲发病率 (60%的重症监护室入院,1名母亲死亡).
结论:
- 在英国,SHiP是一种罕见但严重的疾病,对母亲和胎儿的健康有很大的风险.
- 糟糕的围产期结局和显著的孕产妇发病率/死亡率与SHiP有关.
- 由于案例定义的差异,SHiP的国际比较具有挑战性.
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