乳腺癌患者的右腹腔回声心脏功能,接受基于人环素的化疗:一项前性研究
Kamran Mohammadi1, Mohammad Gertasi1, Mortaza Raeisi2
1Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Caspian journal of internal medicine
|June 27, 2025
概括
人环素化疗可以损害乳腺癌患者的右心室 (RV) 功能,随着时间的推移减少RV无壁应变表明. 在治疗期间,通过心声学监测RV功能至关重要,以检测心脏毒性的早期迹象.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- 人环素是乳腺癌和淋巴瘤的重要化疗剂.
- 这些药物可以引起显著的心脏毒性,重点是左心室 (LV) 功能.
- 在这种情况下,对右心室 (RV) 功能的理解较少.
研究的目的:
- 评估在接受 antracycline 化疗的乳腺癌患者的RV回声心脏学功能.
- 为了在治疗期间和治疗后识别VR功能的变化.
- 为了研究化疗和RV心脏毒性之间的关系.
主要方法:
- 一组72名接受 antracycline 治疗的乳腺癌患者.
- 在基线,治疗中期和治疗后进行心声扫描.
- 使用SPSS V22.22分析无RV壁应变,RV静脉压和其他心脏参数.
主要成果:
- 在最后一次化疗疗程15天后 (P=0.044) 观察到无RV壁壁应变的显著下降.
- 在治疗结束时,异常无RV壁拉伸的患病率显著增加 (P=0.037).
- 右心室缩压 (RVSP) 显著增加 (P=0.035),而LV功能参数保持稳定.
结论:
- 抗环素化疗会随着时间的推移对无RV的壁张产生负面影响.
- 监测RV功能,特别是通过应变成像,对于早期检测亚临床RV功能障碍至关重要.
- 视频回路功能评估应补充在人环素治疗期间的视频回路监测.
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