身体活动和肝酶升高:来自PERSIAN Guilan队列研究的横截面研究
Heydar Ali Balou1, Farahnaz Joukar1, Milad Shahdkar1
1Gastrointestinal and Liver Disease Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Caspian journal of internal medicine
|June 27, 2025
概括
定期的体力活动与较低的肝酶水平有关. 较高的活性与阿氨基转移酶 (ALT) 和马-氨基转移酶 (GGT) 升高的几率降低相关,这表明肝脏健康状况改善.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 临床生物化学 临床生物化学
背景情况:
- 身体活动被认为具有广泛的健康益处,包括对肝功能和关键肝酶调节的显著影响.
- 肝酶升高可能表明肝脏受损或疾病,使其与生活方式因素的关联成为研究的关键领域.
研究的目的:
- 调查不同程度的体力活动与肝酶升高的发生率之间的关系.
- 评估参与伊朗成年人前性流行病学研究研究 (PERSIAN) 吉兰队列研究 (PGCS) 的成年人群中这种关联.
主要方法:
- 从PGCS队列中对10,519名参与者的横截面分析,收集人口统计和临床数据.
- 肝酶水平 (ALT,AST,ALP,GGT) 和体力活动强度使用标准化问卷和生化分析进行测量.
- 使用统计分析,包括Cochran-Armitage趋势测试和后勤回归测试,检查身体活动与肝酶升高之间的关联.
主要成果:
- 在体力活动水平和ALT,AST和GT升高的患病率之间观察到显著的反向关系 (分别p<0.001,p=0.010,p<0.001).
- 与高体力活动的人相比,体力活动较低的人的ALT (OR=1.15) 和GGT (OR=1.37) 升高的几率更高,即使经过调整以考虑混因素.
- 参与者的平均年龄为51.52±8.90岁,其中53.6%是女性.
结论:
- 较高的定期体育活动水平与肝酶升高的患病率降低有关.
- 这些发现表明,促进体育活动可能是维持和改善成年人群肝脏健康的有益策略.
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