心力衰竭药物治疗和预后:一个回顾性横截面研究
Qiankai Lin1, Zongjie Lv2, Daiyi Li1
1Department of Pharmacy, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in pharmacology
|June 27, 2025
概括
针对心力衰竭 (HF) 的指南导向医学治疗 (GDMT) 正在改善,随着推药物的使用增加. 特定的药物,如ARBs,RNAIs和SGLT-2抑制剂,显著减少了HF患者的再入院.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 心力衰竭 (HF) 是全球发病率和死亡率的主要原因,给经济带来重大负担.
- 指南导向医学疗法 (GDMT) 是基于临床指南和临床试验的标准药理治疗HF.
- 这项研究检查了住院HF患者的药物处方模式和再入院率.
研究的目的:
- 描述住院心力衰竭患者的药物处方模式.
- 分析指南导向医疗疗 (GDMT) 与医院再入院率之间的关系.
- 评估药剂师参与对GDMT利用的影响.
主要方法:
- 从2016年1月到2021年6月,对5356名高温肺炎患者进行了回顾性横截面研究.
- GDMT定义为指导方针推的任何HF药物的处方.
- 多层次的逻辑回归分析,以确定药物使用和再入院率之间的关联.
主要成果:
- 通常使用的药物包括MRA (69.3%) 和β-阻断剂 (54.2%).
- 观察到RNAI (12.7%) 和SGLT-2i (8.1%) 的利用率较低,尽管使用率在增加.
- ARB,RNA,抗凝固剂,托尔瓦普坦和SGLT-2i显著降低了再接收率.
结论:
- GDMT药物的使用正在增加,特别是在药剂师参与的情况下.
- 大多数指导方针推的药物在减少HF再入院方面都显示出治疗效益.
- 尽管目前使用率较低,但SGLT-2i和伊瓦布拉丁显示出显著的治疗效果.
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