睡眠质量及其与炎症性肠病患者疾病活动的关联:一个元分析
Xin-Yi Su1, Yi-Nuo Wang1, Yu-Hong Huang1
1Gastroenterology, First Hospital of China Medical University.
Revista espanola de enfermedades digestivas
|June 27, 2025
概括
睡眠不足在炎症性肠病 (IBD) 中很常见,影响到60%的患者. 活跃IBD的睡眠质量较差,性结肠炎和克罗恩病之间的睡眠质量相似.
科学领域:
- 胃肠病学 胃肠病学
- 睡眠医学 睡眠医学
- 公共卫生 公共卫生
背景情况:
- 炎症性肠病 (IBD),包括性结肠炎 (UC) 和克罗恩病 (CD),因其系统性影响而越来越受认可.
- 关于IBD与睡眠质量之间的联系的现有研究提出了不一致的发现.
- 这一元分析解决了对IBD患者睡眠质量的全面评估的需求.
研究的目的:
- 确定IBD患者睡眠质量差的整体患病率.
- 为了比较IBD患者和健康对照者的睡眠质量.
- 调查IBD疾病活动和睡眠质量之间的关联,区分UC和CD.
主要方法:
- 进行了系统的文献搜索,直到2025年2月,包括报告IBD队列睡眠质量的研究.
- 计算了睡眠不足的综合患病率,几率比率 (ORs) 和标准化平均差异 (SMDs).
- 使用科克兰的Q和I2统计数据来评估异质性,以确保可靠的分析.
主要成果:
- 分析包括55项研究,显示IBD患者睡眠不足的患病率为60%.
- 与对照组相比,IBD患者的睡眠不良概率显著增加 (OR:1.90).
- 睡眠不足在活跃IBD (68%) 中更为普遍,并且与活跃疾病 (OR:2.09) 密切相关,特别是在克罗恩病中.
结论:
- 睡眠不足是炎症性肠道疾病中非常普遍的问题,特别是在活跃的疾病爆发期间.
- 在性结肠炎和克罗恩病患者之间,睡眠质量没有显著差异.
- 将睡眠评估和管理整合到IBD护理中,对于改善患者的治疗结果至关重要.
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