患有性综合征的儿童的长度药物坚持和与疾病结局的关联
Cal Robinson1,2, Nowrin Aman2,3, Harshita Arora2
1Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada.
概括
药物不服药在患有脏综合征的儿童中很常见,但似乎不会影响疾病复发,治疗变化或住院治疗. 这一发现表明,目前的坚持监测可能需要对这种情况进行重新评估.
科学领域:
- 儿科脏病学 儿科脏病学
- 药理学坚持研究 药理学坚持研究
- 慢性疾病管理 慢性疾病管理
背景情况:
- 患有性综合征的儿童面临着严重的药物负担和副作用,可能导致不坚持.
- 了解坚持模式对于优化疾病控制和预防儿科综合征并发症至关重要.
研究的目的:
- 为了研究患有性综合征的儿童药物坚持的纵向模式.
- 确定药物不服药与主要疾病结果之间的关联,包括复发率,治疗修改和住院治疗.
主要方法:
- 对患有性综合征的儿童 (1-18岁) 预期观察队伍的分析.
- 使用药物坚持调查问卷 (MAQ) 进行长达五年的年度自我报告药物坚持评估.
- 一般化的线性混合模型用于评估非坚持 (MAQ分数≥1) 和后续结果之间的关联.
主要成果:
- 在735名儿童中,31%的儿童至少一次报告了不服药,五年来这一比例保持稳定.
- 不坚持与复发率的增加 (aRR 1.14),使用类固醇节约药物 (aOR 0.90),rituximab使用 (aOR 0.77),或住院治疗 (aOR 1.17) 并没有显著关联.
结论:
- 自我报告的药物不服药在大约三分之一的儿科性综合征患者中很普遍.
- 目前的研究结果表明,自我报告的不坚持不影响后续的疾病复发,类固醇节约治疗的开始,或住院治疗在这个队列.
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