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Updated: Sep 17, 2025

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In Vitro Assay to Study Tumor-macrophage Interaction
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抗癌治疗影响肺癌瘤相关巨细胞中的TREM2
Yoon Jin Cha1, Eun Hye Lee2, Chi Young Kim2
1Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
Cancer research and treatment
|June 27, 2025
概括
在肺腺癌中,抗癌疗法会改变在髓状细胞 (TREM2) 上表达的触发受体. 化疗影响TREM2表达的巨细胞,影响瘤微环境,并为向治疗提供了洞察力.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 在骨髓细胞表达的触发受体 (TREM2) 有助于免疫抑制瘤微环境 (TME).
- 抗癌治疗对TREM2表达及其在TME中的作用的影响仍然不完全理解.
- 肺腺癌是一种显著的恶性瘤,了解免疫细胞动态至关重要.
研究的目的:
- 为了研究化疗对肺腺癌TME中的TREM2表达性巨细胞的影响.
- 阐明抗癌药物如何调节TREM2和相关的髓状细胞群.
- 了解TREM2+细胞在肺癌治疗中的功能影响.
主要方法:
- 从人类和小鼠肺癌组织和正常肺组织中分析单细胞RNA测序数据集.
- 利用THP-1细胞系来模拟药物对髓状细胞极化和TREM2表达的影响.
- 使用Kras-G12D小鼠肺癌模型来评估体内治疗的影响.
主要成果:
- 在瘤微环境中确定了髓状细胞,特别是TREM2过度表达的子集群.
- 西斯普拉丁治疗增加了肺瘤中TREM2+M2巨的比例.
- 抗癌药物诱导TREM2表达并改变THP-1细胞中的巨细胞极化状态,影响着细胞活动.
结论:
- 抗癌疗法通过调节TREM2+细胞,显著影响肺部免疫微环境.
- 改变的TREM2表达和巨细胞两极分化表明TME重塑和免疫反应调节的作用.
- 研究结果强调,在开发新型TREM2向疗法时,需要考虑化疗对TREM2的影响.
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