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放射治疗对大脑的影响:对管理的影响
Bayle Smith-Salzberg1, Kristin Hsieh2, Daniel Cherry2
1College of Medicine, State University of New York (SUNY) Downstate Health Sciences University, Brooklyn, NY, USA.
Chinese clinical oncology
|June 27, 2025
概括
脑瘤的放射治疗 (RT) 提供了有效的瘤控制,但可能导致急性和延迟的毒性. 了解这些辐射诱导的大脑并发症对于平衡治疗效益与患者安全至关重要.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 放射治疗 (RT) 是治疗内恶性瘤的基石,包括原发性脑瘤和转移.
- 通过诱导DNA损伤,促进细胞亡和抑制癌细胞增殖来发挥RT的功能.
- 在RT技术的进步提高了精度,提高了瘤根除,同时尽量减少对健康的大脑组织的损伤.
研究的目的:
- 审查急性和延迟辐射诱导的大脑毒性的机制,症状和管理.
- 为了突出特定的并发症,如辐射亡,认知障碍和二次恶性瘤.
- 强调平衡RT疗效与不良结果风险的重要性.
主要方法:
- 关于辐射诱导的大脑毒性的文献综述.
- 毒性的分类为急性,早期延迟和晚期延迟.
- 讨论病理生理机制,临床表现和治疗策略.
主要成果:
- 内RT可以导致一系列的毒性,影响生活质量和长期结果.
- 确定的并发症包括昏昏欲睡综合征,辐射亡,认知障碍和SMART综合征.
- 还讨论了像ALERT综合征这样的特定综合征.
结论:
- 对于临床医生来说,全面了解辐射诱导的大脑毒性是必不可少的.
- 在辐射治疗规划中,平衡治疗效益与潜在的不良影响至关重要.
- 有效的管理策略是必要的,以减轻毒性和改善患者的结果.
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