乳糖可选择性地刺激肠道微生物群的成员,通过基于多模式活动的分类来确定
Hamid Rasoulimehrabani1,2, Alessandra Riva1,3, Deniz Inan1
1Center for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystem Science, University of Vienna, Vienna, Austria.
Gut microbes
|June 27, 2025
概括
乳糖是一种潜在的益生菌,可以选择性地刺激有益的肠道细菌,如Bifidobacterium. 它还促进了物种间的合作,并激活了重要的代谢类型,这表明了更广泛的健康益处.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 食补充剂旨在促进有益的肠道细菌.
- 益生菌的选择性需要彻底调查.
研究的目的:
- 评估乳糖对人类肠道微生物群的刺激.
- 研究乳糖作为益生菌的选择性和机制.
主要方法:
- 基于活体多模式活动的细胞分类.
- 拉曼激活细胞分类用于细菌隔离.
- 共同培养实验,以评估物种间相互作用.
主要成果:
- 乳酪糖可以选择性地刺激特定的细菌属,特别是Bifidobacterium,Collinsella和Lactococcus.
- 大多数对乳糖敏感的分离物能够降解乳糖;通过共同培养,增强了Lactococcus lactis的生长.
- 乳糖激活了代谢重要和与健康相关的种类,包括Faecalibacterium和Gemmiger.
结论:
- 乳糖通过促进特定的有益细菌,显示出选择性益生菌潜力.
- 跨物种促进在肠道微生物群中的乳糖利用中发挥着作用.
- 乳糖可能提供更广泛的功能益处超出组合转变,支持其作为食补充剂的使用.
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