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Updated: Sep 17, 2025

Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
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Published on: July 17, 2020

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光敏剂重新定位为 [2 + 2] - 循环添加提供了一个对抗补充酶

Chuanjie Sun1, Anna R Kohn1, Ross Smithson1

  • 1Department of Chemistry & Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.

Angewandte Chemie (International ed. in English)
|June 27, 2025
PubMed
概括

研究人员设计了一种新型的光酶,用于酶选择性 [2+2] - 循环添加. 这一突破使得能够获得具有高选择性的循环butan产品的两个反体系列.

关键词:
生物催化剂是一种生物催化剂.定向进化是指导进化的.遗传密码扩展 遗传密码扩展光催化作用的光催化蛋白质工程是一种蛋白质工程.

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The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
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