在2019年至2022年期间,在日本社区获得的肺炎球菌肺炎的成年人中血清型分布:一项多中心观察性研究
Haruka Maeda1, Isao Ito2, Eiichiro Sando3,4
1Department of Respiratory Infections, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
Human vaccines & immunotherapeutics
|June 27, 2025
概括
像PCV20和PCV21这样的新型肺炎球菌结合疫苗 (PCV) 在日本有望预防成人社区获得的肺炎. 这些疫苗覆盖了大量流通的血清型,因此需要审查目前的成年人疫苗接种政策.
科学领域:
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
- 流行病学 流行病学
背景情况:
- * 肺炎链球菌是成年人社区获得性肺炎 (CAP) 的主要原因.
- * 儿科肺炎球菌合疫苗 (PCV) 计划改变了成人血清型分布.
- *日本已引入PCV15和PCV20,PCV21正在成人使用中进行审查.
研究的目的:
- * 评估日本成年人肺炎菌肺炎的血清型分布.
- *评估现有和新兴肺炎球菌疫苗对已识别的血清型的覆盖率.
主要方法:
- *从2019年5月到2022年12月对583名成人CAP患者进行多中心观察研究.
- *使用Quellung反应识别和血清类型的肺炎球菌分离物.
- * 分析PCV13,PCV15,PCV20,PPSV23和PCV21的血清型覆盖率.
主要成果:
- *主要的血清型为3 (12.5%),35B (12.0%),15A (7.7%),11A (6.7%) 和23A (6.3%).
- *PCV20和PCV21的覆盖率分别为43.7%和71.9%.
- *3型血清型在养老院居民 (25.9%) 中比社区居民 (11.2%) 更常见.
结论:
- *新兴疫苗PCV20和PCV21在日本显示了对成人肺炎球菌肺炎的大量覆盖.
- * 血清型分布表明这些较新的疫苗可能会增强保护.
- *建议重新评估日本成年人肺炎球菌疫苗接种策略.
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