直接心脏压缩装置用于短期的机械循环支持
Kristof Sarosi1, Thomas Kummer1, Stijn Vandenberghe2,3
1From the Institute of Fluid Dynamics, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland.
概括
一个新的直接心脏压缩 (DCC) 补丁提供机械循环支持 (MCS) 没有血液接触. 该装置在外体模型中表现出与开放胸部心脏压缩相匹配的性能.
科学领域:
- 生物医学工程 生物医学工程
- 心血管研究研究心血管研究
- 医疗设备创新 医疗设备创新
背景情况:
- 目前短期心室辅助的选择是有限的和侵入性的.
- 现有的机械循环支持 (MCS) 设备与血液相互作用,造成风险.
- 直接心脏压缩 (DCC) 为MCS提供了一个不接触血液的替代方案.
研究的目的:
- 评估一种用于短期MCS的新型DCC补丁装置.
- 为了比较DCC补丁装置的性能与开放胸部心脏压缩 (OCCC).
- 评估DCC贴片装置在ex vivo绵羊心脏骤停模型中的有效性.
主要方法:
- 使用了一种ex vivo绵羊心脏骤停 (CA) 心脏模型.
- 将一个新的DCC补丁装置与开放胸部心脏压缩 (OCCC) 进行了比较.
- 通过测量压力,流量和门功能以及评估组织损伤来评估设备的性能.
主要成果:
- DCC补丁装置实现了1.5L/分钟的心脏输出和55mmHg的平均大动脉压力.
- 尽管有直接的上心脏接触,但有效的门功能仍然保持.
- DCC补丁装置的性能与OCCC相美.
结论:
- 新的DCC补丁装置显示了短期机械循环支持的潜力.
- 这种非侵入性方法保持了血液动力学功能和门完整性.
- 结果支持用于各种MCS应用的DCC补丁设备的可行性.
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