基于MRI的前列腺癌风险计算器在澳大利亚队列中的外部验证
Nicole Williams1, Sebastiaan Remmers2, Alex Jay1
1Urology Unit, Flinders Medical Centre, Bedford Park, South Australia, Australia.
ANZ journal of surgery
|June 27, 2025
概括
基于磁共振成像 (MRI) 的前列腺癌风险计算器在澳大利亚得到了验证. 一些计算器表现良好,在以前没有做过活检的患者中,可能减少多达12%的不必要活检.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
背景情况:
- 前列腺癌风险分层对于指导活检决策至关重要.
- 磁共振成像 (MRI) 改善了临床上显著的前列腺癌的检测.
- 经过验证的风险计算器可以帮助个性化医疗保健决策.
研究的目的:
- 在澳大利亚队列中对九个基于MRI的前列腺癌风险计算器进行外部验证.
- 评估这些计算器在预测临床显著前列腺癌方面的表现 (国际泌尿病理学会 [ISUP] 等级组≥2).
- 评估这些工具对优化前列腺活检决策的临床实用性.
主要方法:
- 从2018年5月至2023年3月期间进行活检的患者的回顾性数据收集.
- 使用歧视,决策曲线分析 (DCA),校准和重新校准的九个风险计算器的评估.
- 专门针对以前没有做过活检的患者进行子组分析.
主要成果:
- 52%的患者患有临床显著的前列腺癌 (ISUP等级组≥2).
- RPCRC和Mehralivand风险计算器表现最好;Radtke计算器对以前没有做过活检的患者来说足够.
- 决策曲线分析表明,在减少先前没有做过活检的患者的活检时,潜在的临床净益率高达12%,区分能力超过0.79.
结论:
- 外部验证证实了基于MRI的风险计算器对于前列腺癌诊断的实用性.
- 一台计算器在所有患者中显示出足够的区分能力,而三台则适用于未经活检的个人.
- 系统实施可以在以前没有做过活检的患者中提供12%的临床净益处,从而可能减少医疗负担.
相关概念视频
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
182
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
182
01:27Imaging Studies IV: Magnetic Resonance Imaging
59
Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
59
01:12Relative Risk
361
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
361