捐赠者人乳 细菌微生物组合是由母乳养模式塑造的
Xufei Wang1,2, Xiaoyu Pan3, Fangfei Xiao1
1Department of Gastroenterology, Hepatology and Nutrition, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
概括
哺乳模式显著影响人乳微生物群. 间接母乳养和剖腹产与葡萄球菌的增加有关,而牛奶蛋白质影响了乳酸菌和菌的水平.
科学领域:
- 微生物学 微生物学
- 人类牛奶研究研究
- 婴儿营养 婴儿营养
背景情况:
- 人类牛奶拥有多样化的微生物群体.
- 人母乳微生物群的组成因地理位置和决定性因素而异.
- 影响牛奶微生物群的因素正在调查中.
研究的目的:
- 来自中国上海的捐赠人乳的细菌组成的特征.
- 确定影响母乳微生物群组成的因素.
主要方法:
- 252个供母乳样本 (2018年2月 - 2022年7月) 的横截面研究.
- 16S rRNA测序用于微生物群概况.
- 统计分析包括K-means集群,多重线性回归和相关性分析.
主要成果:
- 主要的细菌系是Firmicutes,Proteobacteria,Bacteroidota,以及Actinobacteriota. 这些细菌系是主要的.
- 间接母乳养,早产和剖腹产与较高的葡萄球菌丰度相关.
- 较高的牛奶蛋白与乳杆菌和肠球菌的增加有关;哺乳期显示反向关系.
结论:
- 哺乳模式是人类牛奶微生物组成的关键决定因素.
- 这些发现可以为捐赠人母乳的处理和利用提供信息.
相关概念视频
01:23Anatomy of the Intestines
74.2K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
74.2K
01:22Development of Immunocompetence
454
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
454