相关实验视频

Updated: Sep 17, 2025

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

该cAMP响应元素调节器 (CREM) 转录因子影响了对营养不良和感染的易感性

Audrey C Brown¹, Md Jashim Uddin¹, Rebecca M Munday²

¹Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

|June 27, 2025

概括

在cAMP响应元素调节器 (CREM) 基因的遗传变异与儿童营养不良和Entamoeba histolytica阳性腹有关. 克雷姆会影响体重和免疫反应,提供潜在的治疗点.

科学领域:

遗传学遗传学是一个
免疫学免疫学免疫学
儿科儿科儿科
营养科学营养科学

背景情况:

营养不良和腹性疾病是全球主要的儿童疾病和死亡原因.
这些条件往往相互影响,表明一种共同的遗传基础.
该cAMP响应元素调节器 (CREM) 基因此前与Entamoeba histolytica阳性腹有关.

研究的目的:

调查CREM遗传多态与孟加拉儿童营养不良的关联.
探索CREM在肠道基因表达,新陈代谢和免疫反应中的功能作用.
了解腹疾病和营养不良的共同遗传基础.

主要方法:

在孟加拉国出生队伍中对CREM单核酸多态 (SNPs) 的遗传关联测试.
来自孟加拉国和美国儿童的小肠转录组的分析.
血代谢学概况分析.
在小鼠中进行条件CREM基因删除研究.

主要成果:

与E. histolytica腹相关的CREM SNPs也与儿童的体重与年龄相对z分数较低有关.
具有特定CREM等位基因的儿童的肠道基因表达显示了线粒体功能和免疫反应途径的改变.
鼠标模型表明,CREM删除会影响体重,肠道新陈代谢和免疫基因表达.
组织特异性缺失表明肠上皮的CREM会影响体重和新陈代谢,而其他细胞类型会影响免疫反应.

结论:

肠上皮的CREM表达与体重调节有关,可能是通过线粒体基因表达.
克雷姆会影响对E. histolytica的免疫反应,不同的细胞类型起着不同的作用.
在儿童中,CREM作为关键的转录调节器,将营养不良与腹疾病的易感性联系起来.

关键词:

亚美比亚症是什么意思遗传易感性是一种基因易感性.营养不良营养不良营养不良代谢生物组的代谢生物组翻译学翻译学翻译学翻译学营养不良营养不良营养不良

更多相关视频

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans

Published on: August 16, 2017

相关概念视频

Global Regulatory Systems

Global Regulatory Systems

Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...

Regulation of the Unfolded Protein Response

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...

General Transcription Factors

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...

Master Transcription Regulators

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...

Transduction

Transduction

Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome...