尿路代谢物与癌风险相关联
Thuraya Al-Sayegh1, Shuang Song1, Loren Lipworth1
1Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37203, United States.
Carcinogenesis
|June 27, 2025
概括
这项研究确定了11种与癌风险相关的预诊断性尿代谢物. 特定的脂质,异生菌和核酸具有作为癌检测早期生物标志物的潜力.
科学领域:
- 代谢学 代谢学 代谢学
- 癌症流行病学 癌症流行病学
- 生物标志物发现发现
背景情况:
- 全球癌发病率正在上升.
- 代谢学研究提供了对疾病机制的洞察.
- 很少有研究探讨了预诊断性尿路代谢物和癌风险.
研究的目的:
- 为了前性地研究尿路代谢物和癌风险之间的关联.
- 了解癌的病因学和生物机制.
- 为了确定癌的潜在预诊断性尿路生物标志物.
主要方法:
- 在上海妇女和男性健康研究中进行的一项嵌套病例控制研究.
- 包括200例初级癌病例和匹配的对照.
- 使用条件后勤回归和逆向选择对1301种尿路代谢物的分析.
主要成果:
- 11个尿路代谢物仍然与癌风险有显著的关联.
- 相关代谢物包括脂质 (例如,皮科利诺伊尔甘氨酸),异生菌 (例如,β-瓜因丁酸) 和核酸 (例如,艾伦酸).
- 时间滞后分析表明,当样本收集到更接近诊断时,β-瓜因丁和皮科利诺甘氨酸的相关性更强.
结论:
- 前诊断性尿路代谢物,包括脂质,异生菌和核酸,与癌风险有关.
- 特定的代谢物,如β-瓜因丁酸和皮科利诺伊尔甘氨酸,可以作为潜在的早期生物标志物.
- 需要进一步的大规模,多祖先的代谢学研究来验证.
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