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在急性心肌梗塞中,circFOXP1的诊断和功能值

Zheyi Rong¹, Jingyi Yan², Junbo Wei³

¹Department of Cardiovascular Medicine, Renhe Hospital of Baoshan District, Shanghai, China.

Minerva cardiology and angiology

|June 27, 2025

概括

在急性心肌梗塞 (AMI) 患者中,循环RNAs (circRNAs) 的下调. circFOXP1充当诊断标记物,并通过miR-9-3p抑制亡,炎症和氧化应激.

科学领域:

心血管生物学心血管生物学
分子医学是分子医学.
生物标志物发现发现

背景情况:

循环RNAs (circRNAs) 在急性心肌梗塞 (AMI) 的病原发生中发挥作用.
circFOXP1正在研究其在AMI中的潜在诊断和功能意义.

研究的目的:

评估circFOXP1作为AMI的诊断标志物.
阐明circFOXP1在AMI发病过程中的功能性作用.

主要方法:

通过RT-qPCR和ROC曲线分析分析circFOXP1表达.
路西法酶记者测试以确定circFOXP1的目标基因.
在体外 (AC16细胞) 和体内 (小鼠) AMI模型用于评估增殖,亡,炎症和氧化应激.

主要成果:

在AMI患者中,circFOXP1的表达显著下调.
circFOXP1的过度表达减少了亡,炎症 (TNF-α,IL-1β,IL-6) 和氧化应激 (ROS,LDH),同时增加了GSH.
miR-9-3p被确定为circFOXP1的直接标,并调解其影响.

结论:

circFOXP1 作为一种潜在的AMI诊断生物标志物.
在AMI模型中,circFOXP1的过度表达通过miR-9-3p通路减轻了细胞亡,炎症和氧化应激.

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