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Updated: Sep 17, 2025
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Working with Human Tissues for Translational Cancer Research
Published on: November 26, 2015
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跨人群癌症差异的翻译研究计划
Jane C Figueiredo1, Diana Redwood2, Li Li3
1Cedars-Sinai Medical Center, Los Angeles, California.
概括
跨人群癌症差异转化研究计划 (TRPCDP) 创建了来自不同美国人群的结直肠癌瘤生物存储库. 本资源支持分子流行病学研究,以了解癌症差异.
科学领域:
- 在瘤学瘤学.
- 分子流行病学分子流行病学
- 基因组学就是基因组学.
背景情况:
- 癌症发病率和死亡率在人口水平上表现出显著的变化.
- 跨人群癌症差异转化研究计划 (TRPCDP) 于2020年成立,以调查这些差异.
- 结肠直肠癌是了解不同人群癌症差异的一个关键焦点.
研究的目的:
- 建立一个集中,注释良好的结直肠癌瘤生物存储库.
- 促进分子流行病学研究,调查癌症差异.
- 收集全面的数据,包括人口统计,临床信息和多核的个人资料.
主要方法:
- 集中数据采集和协调在三个美国地点.
- 病例控制框架将致命的结直肠癌病例与非致命的对照进行匹配.
- 收集和处理固定在甲,嵌入氨酸中的瘤和正常组织,以进行病理学审查,DNA/RNA提取和组织微阵列构建.
- 多原子和空间分析,包括转录原子,蛋白质原子和微生物组分析.
- 其他与健康相关的因素的地理空间联系.
主要成果:
- 一个虚拟的生物存储库,包含来自不同人群的7,181名患者 (非洲裔美国人,阿拉斯加本土人,西班牙裔,非西班牙裔白人).
- 来自938名患者的组织块被加工用于DNA/RNA提取和组织微阵列构造.
- 选择样本的转录组,空间瘤概况和微生物组数据的可用性.
结论:
- 开发一个临床注释生物存储库,以支持未来的分子流行病学研究.
- 该TRPCDP促进合作研究,社区参与和科学培训.
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