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Updated: Jul 19, 2026

Vibratome Sectioning Mouse Retina to Prepare Photoreceptor Cultures
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微染色体维护复杂基因是视网膜退化的候选生物标志物

Na Sun1,2,3, Xu Hu4, Jianhui Wang1

  • 1Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Tongji University, Shanghai, China.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
|June 27, 2025
PubMed
概括

研究人员在视网膜退化模型中发现了三个关键的DNA复制基因 (MCM4,MCM5,MCM7) 的下调. 这一发现为视网膜细胞死亡引起的视力损伤提供了潜在的新治疗点.

关键词:
复制DNA复制DNA复制DNA复制生物标志物 生物标志物小染色体维护复杂基因的基因视网膜退化 视网膜退化视网膜色素上皮细胞 视网膜色素上皮细胞

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相关概念视频

Genetic Lingo01:11

Genetic Lingo

Overview
Epistasis01:39

Epistasis

In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
Position-effect Variegation02:32

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
Gene Duplication and Divergence02:37

Gene Duplication and Divergence

The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are characterized.
Complementation Tests00:49

Complementation Tests

A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...