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评估活体移植捐赠者资格的eGFR不准确性
Sarrah Lahorewala1, Zheng Yin2, Jacob Kinskey3
1Department of Pathology and Immunology, Baylor College of Medicine, Baylor St. Luke's Medical Center, Houston, TX, United States.
Clinical chemistry
|June 27, 2025
概括
2021年CKD-EPIcr-cys (AS) 方程是评估活捐赠者资格的最可靠方程. 没有经过测试的方程可以可靠地排除不符合条件的捐赠者,突出了需要改进方法的需要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床化学 临床化学
- 移植 移植 移植 移植
背景情况:
- 准确估计膜过率 (GFR) 对于对活体脏捐赠者的评估至关重要.
- 测量的GFR (mGFR) 不总是可用,需要可靠的估计GFR (eGFR) 方程.
研究的目的:
- 将CKD-EPI,FAS和EKFC的eGFR方程与iohexol的mGFR进行比较.
- 在美国人口中确定最佳的eGFR方程,以评估活捐赠者的资格.
主要方法:
- 对1210名脏捐赠候选人的回顾性分析.
- 基于肌素,囊素C或两者的eGFR方程与iohexol mGFR的比较.
- 评估准确度指标 (P10,P30,平均偏差) 和子组分析.
主要成果:
- 2021年的CKD-EPIcr (AS) 方程显示了最好的整体准确度 (P10 48.2%).
- 2021年CKD-EPIcr-cys (AS) 方程在黑人捐赠者 (P10 60.3%) 和识别可接受的捐赠者 (F1得分83.9在≥90mL/min/1.73m2) 中表现出色.
- 囊素C方程式低估了老年捐赠者的GFR;没有方程式可靠地拒绝了不合格的捐赠者 (<60毫升/分钟/1.73米2).
结论:
- 没有经过测试的eGFR方程可靠地确定了不符合条件的脏捐赠者.
- 2021年CKD-EPIcr-cys (AS) 方程显示了评估捐赠者资格的最佳整体表现.
- 年龄/性别特定的门提高了捐赠者资格分类的准确性.
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