在儿童自闭症谱系障碍:一个随机的,开放标签的临床试验的效果
Samaneh Zare1, Hamid Reihani2, Razieh Taghizadeh Sarvestani3
1Department of Pediatric Neurology, Shiraz University of Medical Sciences, Shiraz, Iran.
Journal of autism and developmental disorders
|June 27, 2025
概括
对自闭症谱系障碍 (ASD) 的儿童来说,补充胆没有显著的益处. 需要进一步的研究,然后再考虑在ASD治疗中使用西蒂科林.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 临床药理学 临床药理学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,影响社会互动和沟通.
- 酸,酸的前体,正在研究其潜在的认知增强性质.
- 之前的研究表明,可林可能有益于各种神经疾病.
研究的目的:
- 评估在被诊断患有自闭症的儿童中改善认知和行为功能时,西提科林的疗效.
- 为了评估胆对核心ASD症状的影响.
主要方法:
- 一个随机的,开放的,平行设计的临床试验,涉及101名患有ASD的儿童.
- 参与者在2个月内接受了胆 (10毫克/千克肌肉内注射) 或安慰剂.
- 评估ASD症状是使用幼儿自闭症修改检查清单 (M-CHAT) 和吉利安自闭症评分表 (GARS).
主要成果:
- 在基线或治疗2个月后,在基线和对照组之间没有观察到M-CHAT或GARS得分的统计学上显著差异.
- 在任何一个GARS子尺度上,花素没有显示出任何显著的有益影响.
- 该研究发现,在评估的ASD人群中,没有证据表明胆对临床有益.
结论:
- 在患有自闭症谱系障碍的儿童中,服用花素并没有产生显著的临床益处.
- 目前的证据不支持在儿童中使用胆来治疗ASD.
- 需要进一步进行高质量的研究,以确定胆在管理ASD中的任何潜在作用.
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