早产子类型对子女自闭症谱系障碍诊断风险的影响
Morgan R Peltier1,2, Michael J Fassett3,4, Nehaa Khadka5
1Department of Psychiatry and Behavioral Health, Jersey Shore University Medical Center, Neptune, NJ, USA. morgan.peltier@hmhn.org.
Journal of autism and developmental disorders
|June 27, 2025
概括
自发早产 (SPTB) 和指示早产 (IPTB) 都显著增加了孩子患自闭症谱系障碍 (ASD) 的风险. IPTB显示了更大的效果大小,这表明早产子类型和ASD风险的原因不同.
科学领域:
- 产科和妇科 产科和妇科
- 发育儿科 发育儿科
- 流行病学 流行病学
背景情况:
- 过早分娩 (PTB) 包括自发过早分娩 (SPTB) 和指示过早分娩 (IPTB),其对自闭症谱系障碍 (ASD) 风险的影响不清楚.
- 了解PTB亚型与ASD等神经发育结果之间的关系对于有针对性的干预至关重要.
研究的目的:
- 为了比较SPTB或IPTB后出生的儿童中患ASD诊断的风险,与到期出生相比.
- 调查与两个主要的早产子类型相关的ASD风险的潜在差异.
主要方法:
- 利用电子健康记录 (EHR) 数据从337,868个母婴二位数的单独怀孕2010年至2021年之间的数据.
- 员工调整后的危险比率 (adj. 使用95%信心区间 (CI) 评估PTB亚型与ASD诊断之间的关联.
- 分析数据按性别分层,出生时的妊娠年龄 (早期与晚期PTB),以及种族/种族.
主要成果:
- 这两个SPTB (adj. HR=1.69) 和IPTB (adj. 的意思) HR = 2.68) 与 ASD 诊断的风险增加显著相关,相比到期出生.
- IPTB的效果大小比SPTB更大,这表明与ASD风险的关联更强.
- PTB亚型和ASD之间的关联在性别和妊娠年龄之间是一致的,但在非西班牙裔黑人人口中显著缺席.
结论:
- 自发和指示的早产都是儿童ASD诊断的重要风险因素.
- 与IPTB更强烈的关联表明,不同的潜在病因有助于早产方式和ASD发展.
- 种族-种族,特别是非西班牙裔黑人身份,可能会改变早产子类型和ASD风险之间的关系,需要进一步调查.
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