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在糖尿病老鼠中,ZnO纳米颗粒通过GLP-1和氧化应激通路使胰腺功能正常化

Fatemeh Mirzaei¹, Cyrus Jalili², Iraj Khodadadi³

¹Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Biological trace element research

|June 27, 2025

概括

低剂量氧化纳米颗粒 (ZnO NPs) 通过改善代谢参数和保护胰腺β细胞,在治疗糖尿病方面表现有前途. 这项研究证明了ZnO NP.

科学领域:

生物医学科学生物医学科学
纳米技术纳米技术
内分泌学在内分泌学.

背景情况:

糖尿病是一种慢性代谢障碍,其特征是高血糖.
氧化应激,炎症和亡有助于糖尿病中的胰腺β细胞功能障碍.
目前治疗糖尿病的方法有局限性和副作用.

研究的目的:

研究氧化纳米颗粒 (ZnO NPs) 对糖尿病大鼠代谢参数的治疗作用.
评估ZnONP对氧化应激,亡和胰腺病理生理学的影响.
确定ZnONP的安全有效剂量,用于治疗糖尿病.

主要方法:

合成和特征ZnO纳米粒子.
维斯塔雄性大鼠被诱导患有糖尿病,并用5毫克/公斤ZnONP治疗.
评估了血糖,胰岛素,GLP-1水平,氧化应激标志物,炎症标志物和亡.
胰腺组织形态使用TUNEL,H&E和阿尔德海德富辛染色进行了评估.

主要成果:

在糖尿病老鼠中,ZnO NPs (5 mg/kg) 被发现是无毒且有效的.
用ZnONP治疗使血糖正常化,改善GLP-1水平.
ZnO NPs减少了胰腺组织中的氧化应激,炎症和亡.
胰腺的病理变化得到缓解,保护β细胞.

结论:

低剂量ZnONP作为胰岛素敏感剂,对胰腺β细胞表现出保护作用.
ZnO NPs有效地使代谢异常正常化,并改善糖尿病大鼠的胰腺病理生理学.
ZnO NPs代表了治疗糖尿病及其并发症的潜在治疗剂.

关键词:

细胞灭亡 (apoptosis) 是一种死亡的过程.胰岛素是一种胰岛素.肠道肠道肠道纳米医学是一种纳米医学.它们是老鼠,老鼠,老鼠.氧化的氧化是什么

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