在完整的脊髓损伤中,皮质脊髓间歇性theta爆发刺激推进感觉运动功能恢复:随机对照试验的协议
Deeksha Patel1, Rohit Banerjee1, Kamran Farooque2
1Department of Physiology, All India Institute of Medical Sciences, New Delhi, Delhi, India.
JMIR research protocols
|June 27, 2025
概括
间歇性甲突破刺激 (iTBS) 可能改善完全脊髓损伤 (cSCI) 患者的运动和感觉功能. 这种非侵入性技术增强了神经可塑性,可能有助于恢复和生活质量.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 生物医学工程 生物医学工程
背景情况:
- 间歇性爆刺激 (iTBS) 是一种非侵入性神经调节技术,可诱导神经和突触可塑性,对于感觉运动功能的恢复至关重要.
- 脊髓损伤 (SCI) 损害神经元功能,导致感觉运动缺陷. iTBS在促进完全SCI (cSCI) 恢复中的有效性仍在调查中.
- 本研究研究了iTBS在增强皮质脊柱管完整性和可塑性,以恢复cSCI患者的运动和感觉功能方面的潜力.
研究的目的:
- 评估iTBS对皮质脊柱管完整性和可塑性在cSCI患者的影响.
- 评估iTBS在cSCI后恢复运动和感官功能的有效性.
- 探索iTBS在增强神经通信和突触传输中的作用,以改善cSCI中的运动控制.
主要方法:
- 40名患有cSCI的患者 (亚洲A级,18-60岁) 被随机分为安慰剂,重复性TMS和iTBS组,并根据刺激部位 (运动皮质,脊髓,组合) 进行进一步细分.
- 每位患者连续5天每天两次接受10次iTBS治疗.
- 评估包括神经和功能结果,电生理学评估 (TMS单脉冲和对脉冲),生物标志物 (ELISA) 和神经递质 (LC-MS),以及干预前,干预后和1,2,3个月的随访.
主要成果:
- 测量结果包括电生理学参数,ASIA评分,疼痛水平,日常生活活动,生活质量,焦虑,抑郁和SCI相关生物标志物.
- 这项研究旨在确定iTBS在运动和感觉功能恢复,皮质脊髓管刺激性,神经恢复,疼痛调节和皮质重组后受伤的有效性.
结论:
- 与定制康复相结合的iTBS显示出作为改善cSCI患者运动功能的综合策略的前景.
- 这种方法可以显著提高从cSCI康复的患者的整体生活质量.
更多相关视频
14:47Author Spotlight: Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning
Published on: April 21, 2023
2.9K
07:20Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy
Published on: August 9, 2024
1.3K
相关概念视频
01:14Spinal Cord Injury ll: Pathophysiology
Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
01:25Secondary Spinal Cord Injury llI: Pathophysiology
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...