皮罗尼病临床试验中的多样性问题-系统性审查
Marcelo Mass Lindenbaum1, Bernardita M Ljubetic1, Navid Leelani2
1Men's Health Section, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, United States.
皮罗尼的皮罗尼是什么?
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 临床试验 临床试验
- 健康差异 在健康上的差异
背景情况:
- 临床试验的多样性对于可概括的结果至关重要.
- 泌尿病学临床试验显示,多样性显著缺乏.
- 皮罗尼病 (PD) 试验需要对种族和种族代表性的评估.
研究的目的:
- 评估已发表的皮罗尼病临床试验中的种族和种族多样性.
- 确定PD研究中代表性不足的种族和民族群体.
主要方法:
- 2024年9月,对英语PD临床试验进行了系统审查.
- 我们搜索了Ovid,Embase和Medline/PubMed数据库.
- 纳入标准侧重于PD临床试验,在标题/摘要中指定病情;排除标准适用于先天性曲率,聚合分析和不完整数据.
主要成果:
- 在包括的75项研究中,只有10项 (13.3%) 报告了1948名男性的种族/种族.
- 白人男性占参与者的95.6%,而其他群体 (黑人,亚洲人,美洲原住民,西班牙裔) 代表性明显不足.
- 基于美国的研究显示,与2020年人口普查数据相比,存在显著差异 (P < .001).
结论:
- 皮罗尼氏病的临床试验显示,非高加索种族和民族群体的代表性明显不足.
- 目前的试验人口统计数据可能会限制研究结果对更广泛的患者群体的概括性.
- 进一步的研究优先考虑多样化的参与者招生对于公平的PD治疗进展至关重要.
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