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Updated: Sep 17, 2025

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

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机器学习应用程序用于预测含有非正规氨基酸的和HLA-A0201之间的结合亲和力

Shan Jiang1, Zhaoqian Su1, Nathaniel Bloodworth2

  • 1Department of Chemistry and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.

PloS one
|June 27, 2025
PubMed
概括

我们开发了一种机器学习工具,以预测非正规氨基酸 (NCAAs) 与I类主要基因相容性复合体 (MHC-I) 的结合程度. 这推动了新疗法的设计,提高了疗效.

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Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

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Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

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Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
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