老年营养风险指数与患有外围动脉疾病的患者全因死亡率之间的关系
1The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
PloS one
|June 27, 2025
概括
低老年营养风险指数 (GNRI) 表示的营养不良与周围动脉疾病 (PAD) 患者的死亡率更高有关. 改善营养可能会减少这一群体的长期死亡风险.
科学领域:
- 心血管科学 心血管科学
- 营养科学 营养科学
- 老年学是指老年学的学科.
背景情况:
- 周围动脉疾病 (PAD) 是一种普遍存在的动脉样硬化疾病.
- PAD与四肢功能障碍和死亡率增加有关.
- 营养不良是PAD患者长期死亡的重要危险因素.
研究的目的:
- 研究老年营养风险指数 (GNRI) 与PAD患者的长期全因死亡率之间的关联.
- 为了确定有针对性的营养干预措施的高风险人群.
- 探索营养不良在PAD预后中的作用.
主要方法:
- 使用了来自国家健康和营养检查调查 (NHANES) (1999-2004) 的数据,其中包括532名PAD患者.
- 采用了卡普兰-梅尔生存分析和多变量考克斯回归模型.
- 进行了子组分析,以检查人口和疾病特征之间的差异.
主要成果:
- 在PAD患者中,GNRI与长期死亡风险之间观察到显著的负相关性 (HR:0.950).
- 高GNRI四分位数 (第三和第四) 与第一四分位数相比,与显著降低的死亡风险有关.
- 通过限制性立方脊线分析证实了GNRI和全因死亡率之间的线性负相关性.
结论:
- 在PAD患者中,GNRI和全因死亡率之间存在显著的负相关性.
- 营养不良似乎是影响PAD预后的关键因素.
- 建议对营养不良的早期发现和干预,以减轻PAD患者的长期死亡风险.
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