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Updated: Sep 17, 2025

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry
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通过VIRMA介导的m6,一种修饰通过调节核糖体生物生成来调节前脑形成

Min Wu1,2,3,4, Xiaoli Wu1,2,4,5, Haifeng Sun6

  • 1Shenzhen Neher Neural Plasticity Laboratory, Shenzhen Key Laboratory of Drug Addiction, the Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Science advances
|June 27, 2025
PubMed
概括

由VIRMA调解的N-甲基氨酸 (m6A) 修饰对于核糖体生物发生和大脑发育至关重要. 维尔玛的枯竭会损害蛋白质合成,导致神经前体细胞死亡和发育缺陷.

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