全球健康风险潜伏在抗性牲畜中
Bintao Li1,2,3, Lan Jiang1,2,3, Timothy Johnson4
1Interdisciplinary Research Center for Soil Microbial Ecology and Land Sustainable Productivity in Dry Areas, Northwest A&F University, Shaanxi 712100, China.
Science advances
|June 27, 2025
概括
牲畜便含有大量抗生素耐药性基因 (ARG),这些基因可以传播给人类. 这项研究绘制了全球牲畜耐药性风险的地图,强调了对抗生素管理的必要性,以减轻临床传播.
科学领域:
- 环境微生物学环境微生物学
- 基因组学就是基因组学.
- 公共卫生 公共卫生
背景情况:
- 在畜牧业中过度使用抗生素使得便成为抗生素耐药性基因 (ARG) 的关键来源.
- 全球分布,驱动因素和牲畜抗体的临床传播潜力尚未得到充分了解.
- 了解牲畜耐药性对公共卫生和抗菌药物管理至关重要.
研究的目的:
- 综合评估全球畜牧业的抵抗力.
- 确定ARG从牲畜到人类的驱动因素和传播途径.
- 为畜牧业相关的ARG开发一个风险评估框架.
主要方法:
- 分析了来自26个国家的4017个牲畜便元基因组.
- 建立一个全面的牲畜ARG和元基因组组装基因组的综合目录.
- 开发一个风险评估框架,整合流动性,临床意义和宿主相关性.
主要成果:
- 畜牧业的抗体是已知的ARG (2291个亚型) 和潜在的ARG (3166个亚型) 的大量储备.
- 牲畜抗体很容易连接到人类抗体.
- 制造了一张全球牲畜抗药性风险地图,突出显示了抗生素管理的影响.
结论:
- 牲畜便代表了具有临床传播潜力的ARG的重要储备.
- 农场和人类医学中的抗生素管理极大地影响了牲畜的抗药性.
- 开发的风险评估框架可以指导未来的研究和政策干预,以打击抗菌素耐药性.
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