Enterococcus faecium bacteriemia:一项多中心观察性研究,重点关注临床和微生物学结果的风险因素
Matteo Rinaldi1,2, Ilaria Rancan3,4, Federica Malerba1
1Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
The Journal of antimicrobial chemotherapy
|June 27, 2025
概括
为了最佳地管理Enterococcus faecium血流感染 (BSI),需要对源控制和随访血液培养来降低30天死亡率. 泰科普拉宁的使用与持续的BSI有关.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 关键护理医学 关键护理医学
背景情况:
- 菌血流感染 (BSI) 的管理仍然低于最佳水平.
- 了解影响BSI结果的关键因素对于改善患者护理至关重要.
研究的目的:
- 调查与Enterococcus faecium BSI.患者死亡率和持续感染相关的可修改的临床因素.
- 在现实临床环境中确定30天死亡率和持续性BSI的预测因素.
主要方法:
- 从2016年1月到2023年12月,对成年患者进行E. faecium BSI的多中心回顾性观察研究.
- 排除在BSI发作后48小时内死亡的患者.
- 统计分析包括考克斯回归和物流二进制模型来评估死亡率和持续的BSI.
主要成果:
- 分析了391名患者;30.3%的人患有抗万科米辛的E. faecium.
- 30天死亡率为34.3%,免疫抑制,SOFA评分,初级BSI和缺乏源控制作为危险因素.
- 持久性BSI发生在18.8%,与较高的CCI,缺乏源控制和提科普拉宁治疗有关.
结论:
- 源控制和及时后续血液培养显著降低了E. faecium BSI的30天死亡率.
- 泰科普拉宁作为向治疗的使用与持续性BSI的更高风险有关.
- 这些发现强调了在管理E. faecium BSI.方面采取具体干预措施的重要性.
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