口服丁酸盐通过修复老年成人肠漏性肠道来改善姿势平衡
Rizwan Qaisar1, M Shahid Iqbal2, Firdos Ahmad1
1Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates; Space Medicine Research Group, Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates; Cardiovascular Research Group, Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates.
酸盐补充剂通过增强肠道屏障功能,增加肌肉力量和步行速度,改善了老年人的姿势平衡. 这项研究表明,丁酸盐作为与年龄相关的姿势不稳定的潜在治疗方法.
科学领域:
- 老年学是一门学科.
- 胃肠病学 胃肠病学
- 神经学 神经学
背景情况:
- 姿势不平衡是老年人普遍存在的问题,通常与肠道透率增加 ("漏肠") 相关.
- 对这种情况的有效干预措施仍然不太了解.
- 这项研究探讨了酸盐补充剂作为一种潜在的治疗策略.
研究的目的:
- 调查口服丁酸盐补充剂对老年男性姿势平衡的影响.
- 评估丁酸盐对肠道透性标记物的影响.
- 为了评估骨肌肉强度和步行速度的变化.
主要方法:
- 一个随机的,安慰剂对照试验,涉及老年男性.
- 参与者接受了口服丁酸盐 (300毫克/天) 或安慰剂16周.
- 测量包括姿势平衡,手握强度 (HGS),步行速度,血中佐努林和脂多糖结合蛋白 (LBP) 的水平.
主要成果:
- 酸盐补充剂显著增加了HGS和步行速度.
- 肠道泄漏的指标血中佐努林和LBP水平在丁酸盐组显著降低.
- 姿势平衡的改善与增强的HGS,步行速度和减少的肠道透性标志物有关.
结论:
- 酸盐补充剂有效地减轻了老年人的姿势不平衡.
- 这些好处似乎是由肠道粘膜修复和改善骨肌肉功能的介导.
- 丁酸盐作为治疗年龄相关姿势不稳定的治疗药物具有前途.
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