评估甲状腺癌风险在类似葡萄糖类-1模拟用户与甲状腺结节的甲状腺癌
Sanjana Balachandra1, Rohma Syed1, Zhixing Song1
1Section of Endocrine Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
The Journal of surgical research
|June 27, 2025
概括
类似于葡萄糖类 (GLP-1) 的类似物在患有甲状腺结节的患者中显示甲状腺癌的发病率较低. 这项研究发现,与甲福明使用者相比,甲状腺癌风险没有显著差异.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 甲状腺结节很常见,具有恶性瘤的潜力.
- 类似于葡萄糖类 (GLP-1) 的类似物与状甲状腺癌的潜在风险增加有关.
- 在用GLP-1类似物治疗结核的患者中评估甲状腺癌发病率至关重要.
研究的目的:
- 评估甲状腺癌发生率在接受GLP-1类似物的甲状腺结节患者中.
- 为了将这种发病率与接受甲福林治疗的队列进行比较.
主要方法:
- 使用TrinetX数据库 (1995-2024) 的回顾性队列研究.
- 包括患有甲状腺结节 (ICD-10-CM E04) 的儿科和成人患者,接受GLP-1类似物 (ATC A10BJ) 治疗.
- 卡普兰-梅尔生存分析比较了GLP-1和甲胺队列之间的甲状腺癌发病率 (ICD-10-CM C73).
主要成果:
- 171,460名患者既有甲状腺结节,也使用了GLP-1类似物.
- 在GLP-1队列中,没有发生甲状腺癌的概率为91.042% (4687例).
- 在GLP-1模拟剂和甲胺队列之间没有观察到甲状腺癌风险的显著差异 (风险比:0.99).
结论:
- 在用GLP-1类似物治疗的甲状腺结节患者中,甲状腺癌的发病率相对较低.
- 与甲胺相比,GLP-1类似物似乎不会显著增加甲状腺癌的风险,在这个人群中.
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