相关实验视频

Updated: Sep 17, 2025

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter

Published on: May 29, 2019

导航复杂的暴露于多类有机污染物在可呼吸大小的颗粒的复杂性和对氧化潜力的影响

Ying-Jie Zhang¹, Ting-Ting Xu¹, Yu-Ling Luan¹

¹Guangdong Key Laboratory of Environmental Pollution and Health, College of Environment and Climate, Jinan University, Guangzhou 511443, China.

Environment international

|June 27, 2025

概括

废物回收厂的颗粒物含有多环芳 (PAH),制阻燃剂 (BFR) 和酸盐 (PAE). 在较粗的颗粒中,高分子量PAH和BFR显著推动氧化潜力,需要有针对性的污染控制.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
大气化学大气化学

背景情况:

长期吸入大气颗粒物 (PM) 在全球造成数百万个过早死亡.
同时存在的有机污染物的氧化潜力 (OP) 的来源和驱动因素尚不清楚.
废物回收厂是复杂空气污染物的重要排放来源.

研究的目的:

研究多环芳 (PAH),制阻燃剂 (BFR) 和酸盐 (PAE) 的尺寸分布,呼吸道沉积和日常暴露.
为了确定来自废物回收工厂的尺寸分割的PM₁₀中基于dithiothreitol的氧化潜力 (OP).
探索共存污染物和非细胞OP之间的颗粒大小相关性.

主要方法:

从四个废物回收工厂采集的PM10样品的纵向研究,采用八级级联列采样器采集.
对41种化学物质的分析,包括PAH,BFR和PAE.
重量定量和回归模型用于评估污染物对OP的贡献.

主要成果:

在PM₁₀中的酸盐 (PAE) 含量明显高 (100-1000倍) 于PAH和BFR.
细颗粒PM_2.1对肺部沉积贡献了37%-73%,而粗颗粒PM_9.0-10沉积在上呼吸道.
高分子量PAHs和BFRs在粗PM分数中在产生OP方面更强大,其中[g,h,i]烯是最重要的贡献者 (22%).

结论:

增加的污染负担并不总是等同于严重的氧化毒性.
颗粒大小和化学成分是影响OP的关键因素.
需要有针对性的策略来减轻可呼吸的颗粒物的氧化毒性,重点关注特定的高强度化合物和颗粒大小.

关键词:

风险投资评估风险投资评估有机污染物有机污染物有氧化潜力可能存在.呼吸系统的沉积呼吸系统的沉积尺寸分成小部分的PM(10)

更多相关视频

Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System

Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System

Published on: December 21, 2016

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

相关概念视频

Types of Toxins

Types of Toxins

Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

Radical Autoxidation

Radical Autoxidation

The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...

Oxygen Requirements and Growth Patterns

Oxygen Requirements and Growth Patterns

Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...