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揭示了具有潜在抗瘤活性的正态基曼尼赫合物:合成,机械学研究,in silico对接和分子动态模拟

Islam M Abdel-Rahman1, Mohamed Abdel-Aziz2, Heba Ali Hassan3

  • 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, New-Minia, Minia, Egypt.

European journal of medicinal chemistry
|June 27, 2025
PubMed
概括

新的曼尼希 (Mannich) 基普洛素-基混杂物显示出强大的抗癌活性. 化合物5j有效地抑制拓酶IIβ,并显示出对癌细胞系的显著细胞毒性潜力,需要进一步研究.

关键词:
抗扩散药物 抗扩散药物石灰是一种的物质.齐普罗夫洛克萨辛的使用方法曼尼希的基础是曼尼希的基础.在NCI的细胞线上.

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All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
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