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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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循环素依赖激酶12影响蛋白激酶D1激酶活动

Sanjeev Shukla1, Jean-Pierre Trey Kanumuambidi1, Reynier Rodriguez Rosales1

  • 1Department of Urology, University of Florida, College of Medicine, Jacksonville, FL, 32209, USA.

Biochemical and biophysical research communications
|June 27, 2025
PubMed
概括

循环素依赖性激酶12 (CDK12) 突变驱动了侵袭性前列腺癌. 这项研究揭示了CDK12与瘤抑制剂蛋白激酶D1 (PrKD1) 直接相互作用,调节其活性,并建议新的治疗点.

关键词:
双分子光补充 (BiFC) 方法共同免疫沉 共同IP循环素依赖性激酶12的作用前列腺癌是什么意思 前列腺癌是什么意思蛋白质激酶 D1 的蛋白质激酶 D1.

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