相关实验视频

Updated: May 14, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

与三角神经疼痛患者的桃体相关纤维通道中的异常白质微观结构:多变量分析

Chuan Zhang¹, Baijintao Sun², Tingdan Deng³

¹Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province 637000, China; Institute of Nanomedicine Innovation and Translational Research, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province 637000, China; Biotechnology Innovation Drug Application and Transformation Key Laboratory of Sichuan Province, North Sichuan Medical College, Nanchong, Sichuan Province 637000, China; Science and Technology and Innovation Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province 637000, China.

The journal of pain

|June 27, 2025

概括

这项研究发现,三角神经疼痛 (TN) 患者的大脑白质路径的改变与负面情绪有关,这表明面部疼痛的神经生物学基础. 针对情绪困扰的早期干预可能会改善结果.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
精神病学是一个精神病学.

背景情况:

三神经疼痛 (TN) 涉及严重的面部疼痛和负面的情绪状态,如焦虑和抑郁.
在TN中,疼痛和情绪之间的神经生物学联系尚未完全理解.

研究的目的:

在TN患者中调查桃体相关的白质路径变化.
探索这些结构变化,疼痛强度和情绪困扰之间的关系.

主要方法:

使用了扩散张力成像 (DTI) 和基于种子的纤维流线分析.
研究了46名TN患者和35名健康对照.
疼痛和情绪困扰的量化使用验证的尺度 (PFPR,MPQ,PCS,PASS).

主要成果:

经过TN的患者表现出小部分异构性 (FA) 的降低和特定白质道中平均扩散率的增加.
更高的疼痛灾难性得分与增加的面部疼痛强度相关.
杏仁体通路中的异常FA部分介导了负面情绪和疼痛强度之间的联系.

结论:

与桃体相关的白质微观结构的改变可能会导致TN中负面情绪和疼痛的相互作用.
疼痛灾难可能会改变大脑结构,加剧慢性面部疼痛.
早期针对负面情绪可以预防大脑结构变化并改善TN结果.

关键词:

扩散张力成像的成像方法多变量分析多变量分析负面情绪负面情绪疼痛的强度疼痛的强度三叉子神经疼痛三叉子神经疼痛

更多相关视频

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Published on: May 23, 2017

相关概念视频

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...