血中阿尔多和宁度对中国成年人血压变化和高血压风险的影响:基于人口的哈卡生物库研究
Fuxiang Fang1, Jingwei Lin1, Mingli Li2
1Institute of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, Guangxi, China; Center for Genomic and Personalized Medicine, Guangxi key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China.
概括
较高的血阿尔多素度 (PAC) 和阿尔多与雷宁比率 (ARR),以及较低的血雷宁度 (PRC),与中国人群中血压升高和高血压风险增加有关. 这些关联在宁抑制或自主阿尔多斯特分泌的情况下尤其明显.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 遗传学和流行病学
背景情况:
- 氨酸-氨酸-阿尔多斯特系统 (RAAS) 在血压调节中起着至关重要的作用.
- 在中国人群中,RAAS成分对血压表型的具体影响仍然不完全理解.
研究的目的:
- 为了研究血阿尔多素度 (PAC),血雷宁度 (PRC) 和阿尔多与雷宁比率 (ARR) 与血压 (BP) 相关的表型之间的关联.
- 在中国的Hakka Biobank队列中描述这些协会.
主要方法:
- 利用回归模型,受限立方线和子组分析.
- 分析了Hakka生物银行队列中8914名参与者的数据.
- 研究了日志PAC,日志PRC和日志ARR与多个BP表型和高血压风险的关联.
主要成果:
- 较高的LOG-PAC和LOG-ARR,以及较低的LOG-PRC,与较高的缩血压,腹缩血压,脉冲压和平均动脉压 (P < .001) 有显著的关联.
- 增加PAC或ARR,降低PRC,与各种高血压风险更高相关 (ORs从1.66到6.29不等).
- 在RAAS成分和高血压之间观察到非线性关联,特别是在宁抑制或自主阿尔多素分泌的条件下.
结论:
- 升高的PAC和ARR,加上降低的PRC,与不良的血压变化和高血压风险增加有关.
- 这些发现凸显了RAAS成分在研究中华人群中高血压发展中的临床意义.
- 这项研究强调了在评估阿尔多斯特对血压的影响时考虑蛋白状况的重要性.
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