功能及其与2型糖尿病中的视网膜微循环和胆道厚度的关联:从cystatin C和肌素的洞察力
Kaiqun Liu1, Yanjie Zhu2, Siqi Chen2
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China; Department of Ophthalmology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Diabetes research and clinical practice
|June 27, 2025
概括
在2型糖尿病 (T2DM) 中,功能障碍与视网膜微血管密度和冠状腺厚度的变化有关. 这些视网膜变化可能有助于检测早期功能障碍,特别是在没有糖尿病视网膜病变的患者中.
科学领域:
- 眼科医生 眼科 眼科
- 腎臟病學 (nephrology) 是一種醫學專業.
- 糖尿病学 糖尿病学
背景情况:
- 2型糖尿病 (T2DM) 与影响脏和眼睛的微血管并发症有关.
- 通过视网膜的微血管变化来评估功能提供了一个潜在的非侵入性诊断方法.
研究的目的:
- 调查T2DM患者功能障碍和黄斑视网膜微血管密度和胸腔厚度之间的关系.
- 探索视网膜成像在识别T2DM早期功能障碍中的实用性.
主要方法:
- 一项涉及1050名T2DM患者的横截面研究.
- 光学一致性断层扫描血管图 (OCTA) 用于测量表面 (SCP) 和深层 (DCP) 毛细管血管密度.
- 光学一致性断层扫描 (OCT) 测量了黄斑胆道厚度 (mCT).
- 评估功能是使用估计的膜过率从cystatin C和肌素 (eGFRcr-cys).
- 进行了回归和分层分析,考虑尿酸水平和糖尿病视网膜病变 (DR).
主要成果:
- 功能下降 (较低的eGFRcr-cys) 与减少的SCP血管密度 (SCP-VD) 和mCT相关,但增加了DCP血管密度 (DCP-VD).
- 经过调整的分析证实了eGFRcr-cys与SCP-VD和mCT之间的积极关联,以及与DCP-VD的负面关联 (P <0.05).
- 这些关联在灵敏度和分层分析中仍然显著,在DR患者和无DR患者中观察到不同的模式.
结论:
- 在T2DM患者的视网膜中的微循环变化反映了潜在的功能障碍.
- 视网膜微血管密度和冠状腺厚度显示出作为检测T2DM早期功能障碍的生物标志物的潜力,特别是在没有糖尿病视网膜病变的情况下.
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