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儿童甲状腺癌中的自身免疫甲状腺炎:临床特征和结果
Michaela Kuhlen1,2, Marina Kunstreich1,2,3, Desiree Dunstheimer1
1Paediatrics and Adolescent Medicine, Faculty of Medicine, University of Augsburg, Stenglinstr. 2, Augsburg 86156, Germany.
European journal of endocrinology
|June 27, 2025
概括
儿童分化甲状腺癌 (paedDTC) 患者的自身免疫甲状腺炎 (AIT) 与较少的远程转移有关. 虽然无事件生存率呈现了改善的趋势,但整体生存率仍然相似,这表明AIT可能会影响小儿甲状腺癌的结果.
科学领域:
- 内分泌学 在内分泌学.
- 儿科瘤学 儿科瘤学
- 甲状腺癌研究研究
背景情况:
- 自身免疫性甲状腺炎 (AIT) 是一种免疫媒介的疾病,影响甲状腺.
- 儿童差异化甲状腺癌 (paedDTC) 是儿童罕见的恶性瘤.
- 需要进一步阐明AIT和paedDTC之间的相互作用.
研究的目的:
- 调查小儿分化甲状腺癌 (paedDTC) 的临床特征.
- 评估paedDTC患者的生存结果,包括患有和没有自身免疫甲状腺炎 (AIT) 的患者.
主要方法:
- 对401名儿科患者 (<18岁) 进行了回顾性队列分析,其基因病理学证实了DTC.
- 患者根据AIT的存在或不存在进行了分层.
- 使用Kaplan-Meier估计来评估生存结果.
主要成果:
- 16.0%的paedDTC患者患有AIT,诊断时年龄明显较大.
- 在AIT患者中,远程转移率明显较低 (7.5%与22.2%相比).
- 在AIT患者中发现了改善无事件生存的趋势,总体存活率相似.
结论:
- 自免疫性甲状腺炎存在于16%的儿科DTC病例中,并与远程转移的减少有关.
- AIT可能与改善无事件生存率和儿童甲状腺癌中类似的整体生存率有关.
- 通过对AIT患者的监测,通过早期检测paedDTC,需要进一步调查潜在机制.
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