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为长期释放抗生素而化的人类骨移植的PLLA涂层

Mike Barbeck1, Jiawei Zhang2, Sanja Stojanovic3,4

  • 1Clinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany; mike.barbeck@med.uni-rostock.de.

In vivo (Athens, Greece)
|June 27, 2025
PubMed
概括

这项研究探讨了从骨移植中持续释放的抗生素,以预防感染. 范科米辛和利芬素显示出最好的抗菌活性,尽管生物相容性需要改进,以加强骨再生.

关键词:
生物相容性 生物相容性MIC9090的价格为90美元.所有的移植都是移植.抗生素敏感性 抗生素敏感性骨移植感染 骨移植感染骨再生 骨再生药物输送是药物输送的过程.在当地提供抗生素.子的小腿骨.

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Drug Distribution: Tissue Binding01:21

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Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
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