接受食道状细胞癌手术的老年患者的结果
Takuya Iguchi1, Satoshi Nakamura2, Masato Kitazawa1
1Division of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
In vivo (Athens, Greece)
|June 27, 2025
概括
消化管切除术对于患有食道状细胞癌的老年患者 (≥75岁) 是一种安全有效的治疗方法,其存活率和并发症风险与年轻患者相似. 这一发现支持对患有这种癌症的老年人进行手术干预.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 老年医学 老年医学
背景情况:
- 食道癌,特别是状细胞癌,是全球男性死亡的重要原因.
- 消化管切除术是主要的治疗方法,但存在风险,特别是对于老年患者.
- 接受食道切除术的老年患者的治疗决定需要仔细考虑,因为侵入性和潜在的并发症.
研究的目的:
- 评估食管切除术对患有食管状细胞癌的老年患者 (≥75岁) 的安全性和长期结果.
- 为了比较老年和年轻患者队列之间的术后并发症和生存率.
- 确定影响ESCC食道切除术患者生存的预后因素.
主要方法:
- 对126名患有食道状细胞癌 (ESCC) 的患者进行了回顾性审查,这些患者接受了食道切除术.
- 对75岁以上的患者 (n=24) 和75岁以下的患者 (n=102) 的比较.
- 对临床特征,手术方法,术后结果和生存数据 (OS,RFS,DSS) 的分析.
主要成果:
- 老年患者的EGFR和白蛋白水平较低,并发病率较高,ASA得分较高,但BMI和病理阶段相似.
- 没有发现年龄组之间的手术细节,出血,术后并发症或住院时间的显著差异.
- 老年患者和年轻患者的生存结果 (5年OS,RFS,DSS) 是可比的,年龄不是一个独立的预后因素.
- 病态N和T阶段被确定为整体存活时间的独立预后因素.
结论:
- 在75岁及以上的患者中,食管切除术的长期结果与年轻患者相似.
- 该程序不会增加老年人群的术后并发症.
- 在ESCC患者中,年龄不应是食管切除术的禁忌,因为生存率和并发症概况相似.
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