基于JADER数据库的分析,分析了三胺酸与血栓栓塞和相关风险因素之间的关联
Natsuko Ishida1, Toshihiro Shibata2, Yukio Suga2
1Faculty of Pharmacy, Institute of Medical, Pharmaceutical & Health Science, Kanazawa University, Kanazawa, Japan naishida@p.kanazawa-u.ac.jp.
In vivo (Athens, Greece)
|June 27, 2025
概括
特兰胺酸 (TXA) 可能会增加静脉血栓塞栓症 (VTE) 的风险. 这种风险在女性和超重个体中似乎更高,因此在TXA使用期间需要仔细监测患者.
科学领域:
- 药物监督 药物监督 药物监督
- 血栓栓塞瘤研究研究
- 药品安全 药品安全
背景情况:
- 特兰胺酸 (TXA) 是一种广泛使用的血液静止剂,具有多种应用.
- 关于TXA与血栓塞栓症的关联现实世界的数据有限.
- 评估潜在的不良事件对于患者安全至关重要.
研究的目的:
- 为了调查三胺酸 (TXA) 和血栓栓塞事件之间的关联.
- 评估与TXA相关的静脉血栓塞栓症 (VTE) 和动脉血栓塞栓症 (ATE) 的风险.
- 为了确定特定的人群在TXA相关的VTE的风险较高.
主要方法:
- 对日本药物不良事件报告数据库的分析 (2004年第一季度 - 2020年第三季度).
- 使用报告几率比率和多变量逻辑回归分析.
- 审查了1,735,923份不良事件报告.
主要成果:
- 在TXA和静脉血栓塞栓症 (VTE) (ROR=6.61) 之间发现了显著的关联.
- 没有检测到动脉血栓栓塞 (ATE) 的显著信号.
- 涉及TXA的VTE病例在女性和BMI≥25.5的个体中更常见.
结论:
- 特兰胺酸 (TXA) 可能与静脉血栓塞栓症 (VTE) 的风险增加有关.
- 医疗保健提供者应谨慎行事,并在TXA施用期间密切监测患者.
- 高风险人群,包括妇女和超重个体,需要特别注意.
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