阻塞性结直肠癌的生存预测因素:一种联合的临床,炎症和细胞病理学方法
Ahmet Tarik Harmantepe1, Adem Şentürk2
1Department of Gastroenterology Surgery, Sakarya University Training and Research Hospital, Sakarya, Turkiye; tarikharmantepe@gmail.com.
术前系统性炎症标志物,如C反应性蛋白与白蛋白比率 (CAR),淋巴细胞与C反应性蛋白比率 (LCR) 和预后营养指数 (PNI),可以预测阻塞性结直肠癌 (oCRC) 的存活率. 对于oCRC患者来说,LCR,CAR和PNI都是有价值的预后指标.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 炎症研究 炎症研究
背景情况:
- 阻塞性结肠直肠癌 (oCRC) 是一个重大的临床挑战,预后不佳,术后发病率高.
- 在oCRC中基于炎症的生物标志物的预后价值尚未得到充分确立.
- 确定可靠的生存预测因素对于管理oCRC患者至关重要.
研究的目的:
- 研究手术前系统性炎症标志物在阻塞性结肠直肠癌 (oCRC) 患者的预后作用.
- 确定各种基于炎症的生物标志物与oCRC的整体存活率之间的关联.
- 确定易于获取的标记,以指导oCRC管理中的临床决策.
主要方法:
- 对于经历了为组织病理学确认的oCRC手术的患者进行了回顾性分析.
- 术前系统性炎症标志物的评估:C反应性蛋白与白蛋白比率 (CAR),淋巴细胞与C反应性蛋白比率 (LCR),预后营养指数 (PNI),中性粒细胞与淋巴细胞比率 (NLR),血小板与淋巴细胞比率 (PLR),系统性炎症指数 (SII) 和HALP得分.
- 对这些标志物与1,3年和5年整体存活率之间的关联进行统计分析.
主要成果:
- 反应性蛋白与白蛋白的比率 (CAR),淋巴细胞与C反应性蛋白的比率 (LCR) 和预后营养指数 (PNI) 与整体存活率 (p <0.05) 有显著关联.
- 淋巴细胞与C反应蛋白比率 (LCR) 在预测死亡率方面表现出最高的灵敏度和特异性.
- 较高的CAR和较低的PNI值与明显较差的患者结局相关.
结论:
- 术前系统性炎症标志物,特别是LCR,CAR和PNI,作为阻塞性结直肠癌 (oCRC) 的有价值的预后指标.
- 这些易于获得的标记物可以帮助临床决策和开发对oCRC的个性化治疗策略.
- 这些发现突出了基于炎症的标志物的潜力,以改善oCRC患者的治疗.
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