虚弱和心脏代谢疾病的变化:从长度队列研究和遗传分析中得到的证据
Wenjie Wang1, Kexin Wang1, Guangyuan Chen2
1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
JACC. Advances
|June 27, 2025
概括
衰弱的恶化显著增加了患心脏代谢疾病 (CMD) 和心脏代谢多病症 (CMM) 的风险. 较高的脆弱性指数和脆弱性的变化也与CMD和CMM风险的增加有关.
科学领域:
- 老年学和老年医学是老年学和老年医学.
- 心血管疾病流行病学
- 公共卫生研究 公共卫生研究
背景情况:
- 心脏代谢性疾病 (CMD),包括冠心病,中风和糖尿病,对健康构成重大挑战.
- 心脏代谢多病症 (CMM) 被定义为具有两个或两个以上的CMD.
- 脆弱性越来越被认为是CMD和CMM的危险因素,尽管研究仍然有限.
研究的目的:
- 调查脆弱性指数 (FI),脆弱性状态变化和发展CMD和CMM的风险之间的关联.
- 分析不同程度的脆弱性和脆弱性变化如何影响心脏代谢健康结果.
主要方法:
- 利用了来自中国健康与退休长度研究 (CHARLS) 的数据.
- 参与者被分为强壮 (FI ≤0.1),预先脆弱 (FI 0.1-0.25) 和脆弱 (FI ≥0.25) 的类别.
- 采用了总FI和FI变化 (ΔFI) 的三元分析,并利用门德尔随机化对FI和CMD关系的遗传洞察.
主要成果:
- 从强壮状态向前脆弱/脆弱状态的进展显著增加了CMD (HR: 1.67) 和CMM (HR: 1.80) 的风险.
- 总FI的高三位数 (三位数2 HR: 1.48,三位数3 HR: 2.11) 和 ΔFI (CMD的HR: 1.61,CMM的HR: 2.07) 与最低三位数相比,与CMD和CMM风险增加有关.
- 这项研究包括10,022名参与者 (54.0%是女性,中位数年龄为57岁).
结论:
- 虚弱状态的恶化是心脏代谢疾病和多病症风险增加的重要预测因素.
- 较高的总脆弱指数和较大的脆弱变化独立地与较高的CMD和CMM风险有关.
- 这些发现强调了在心脏代谢健康的背景下监测和管理脆弱的重要性.
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