横向静脉鼻腔支架与异常发病性内高血压中脑脊液分流:一个多机构和多国数据库研究的多机构和多国数据库研究
Jarunee Intrapiromkul1, Ansaar T Rai1,2,3,4, Dhairya A Lakhani5,2,3,4
1Department of Neuroradiology, WVU Rockefeller Neuroscience Institute, Morgantown, West Virginia, USA.
Journal of neurointerventional surgery
|June 27, 2025
概括
横向静脉鼻 (TVS) 支架提供较低的治疗失败和医疗保健使用与脑脊液 (CSF) 转移相比,与异常性脑内高血压 (IIH) 相比,尽管声可能会持续. 这两种治疗方法都能改善症状,减少药物需求.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 血管外科 血管外科
背景情况:
- 异常性内高血压 (IIH) 是一种疾病,对治疗选择的比较数据有限.
- 脑脊液 (CSF) 转移和横静脉鼻腔 (TVS) 支架是IIH的关键干预措施.
- 了解这些治疗方法的比较有效性对于患者管理至关重要.
研究的目的:
- 为了比较TVS支架的疗效和安全性与成年IIH患者的CSF转向.
- 评估治疗失败率,症状缓解,药物使用和医疗保健利用情况.
- 提供大规模的,对这两种突出的IIH治疗方法的比较数据.
主要方法:
- 使用TriNetX平台进行了一项跨国,多机构的回顾性分析.
- 倾向性得分匹配被用来比较成人IIH患者接受TVS支架与CSF分流.
- 结果包括治疗失败,残留症状,药物使用和1年随访时的医疗利用.
主要成果:
- 与CSF转移相比,TVS支架的重复干预率明显较低 (9.6%与38.6%相比).
- 接受TVS支架的患者出现了较少的残留头痛,视力障碍和 papilledema.
- TVS支架与减少非计划的医院再入院和急诊室访问有关,但脉动性耳的发病率更高.
结论:
- 两者TVS支架和CSF变流改善症状,减少IIH患者的药物需求.
- 在治疗失败,症状控制和医疗利用方面,TVS支架显示出优异的结果.
- 持续的脉动性耳是一个值得注意的副作用,应考虑TVS支架.
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