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Updated: Sep 17, 2025

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通过多重复制分子动力学模拟和马尔科夫状态建模,探索神经美丁B受体的独特激活机制

Nuan Li1,2, Ming-Yuan Yang3, Ming-Yang Zhang1,2

  • 1Department of Pharmaceutical and Artificial-Intelligence Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Acta pharmacologica Sinica
|June 27, 2025
PubMed
概括

这项研究揭示了神经胺B受体 (NMBR) 配体的独特结合模式和激活机制. 这些发现提供了有关传播的见解,以及针对G蛋白结合受体 (GPCRs) 的潜在抗治疗方法.

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