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Updated: Sep 17, 2025

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在患有固体瘤的患者中使用defactinib与avutometinib:第一阶段FRAME试验

Susana Banerjee1, Matthew G Krebs2, Alastair Greystoke3

  • 1Gynecological Oncology Unit and Division of Clinical Studies, The Royal Marsden Hospital Foundation Trust and The Institute of Cancer Research, London, UK.

Nature medicine
|June 27, 2025
PubMed
概括

这项首次在人身上进行的试验结合了avutometinib (RAF-MEK) 和defactinib (FAK抑制剂) 治疗固体瘤. 该组合显示出有前途的抗瘤活性,特别是在低度血清性卵巢癌中,并确定了推的第二阶段剂量.

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