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相关概念视频

iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Tissue Renewal without Stem Cells01:23

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
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治疗糖尿病的干细胞疗法

Juin Ting Chen1,2, Nidheesh Dadheech3,4, Eddie Han Pin Tan5

  • 1Stem Cells and Diabetes Laboratory, Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.

Nature medicine
|June 27, 2025
PubMed
概括

人类干细胞衍生的胰腺小岛状细胞为糖尿病治疗提供了有前途的解决方案,解决了胰岛素治疗供体细胞的严重短缺问题. 进一步的研究和监管导航是这种细胞治疗突破的关键.

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科学领域:

  • 内分泌学 在内分泌学.
  • 再生医学是一种再生医学.
  • 干细胞生物学 干细胞生物学

背景情况:

  • 糖尿病会给全球的健康和经济带来巨大的负担.
  • 目前的治疗方法无法解决胰腺生产胰岛素的β细胞的逐渐丧失.
  • 现有的人类小岛细胞移植面临着供体供应的限制.

研究的目的:

  • 审查从人类多能干细胞中获得胰腺小岛样细胞的科学进展.
  • 分析使用干细胞衍生小岛状细胞的临床试验进展情况.
  • 讨论这种新型糖尿病治疗的临床应用的监管障碍.

主要方法:

  • 关于干细胞分化成胰腺小岛样细胞的最新科学文献的综述.
  • 分析正在进行和已完成的临床试验数据.
  • 检查基于细胞的治疗方法的监管途径和要求.

主要成果:

  • 从人类多能干细胞生成功能性胰腺小岛样细胞方面取得了重大进展.
  • 早期的临床试验显示了干细胞衍生细胞在恢复葡萄糖平衡中的潜力.
  • 关键的挑战仍然在于细胞生存,功能和长期疗效.

结论:

  • 人类干细胞衍生的胰腺小岛状细胞代表了糖尿病治疗的潜在可扩展的解决方案.
  • 克服科学和监管方面的挑战对于临床翻译至关重要.
  • 这种方法预示着细胞治疗治疗糖尿病的新时代.