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微生物重要:探索婴儿肠道微生物群与骨发育之间的联系
Perry Caviness1, Bharath K Mulakala2,3, Oxana P Lorenzo1
1Arkansas Children's Nutrition Center, Little Rock, AR, USA.
Calcified tissue international
|June 27, 2025
概括
人母乳,从分泌或非分泌母亲,支持婴儿的骨发育. 婴儿配方奶粉可能通过改变肠道微生物组合来阻碍骨的生长,从而影响关键的生长因素.
科学领域:
- 微生物学 微生物学
- 发展生物学 发展生物学
- 营养科学 营养科学
背景情况:
- 人母乳是婴儿最佳营养,影响微生物群和生理发育必不可少的生物分子生产.
- 通过fucosyltransferase-2 (FUT2) 表达来确定母体的分泌者状态,影响人乳寡糖化合物的组成.
- 婴儿肠道微生物组的组成是由牛奶因素塑造的,这可能会影响整体发育.
研究的目的:
- 调查分泌 (SMM) 和非分泌 (NSM) 母乳和婴儿配方奶 (MFM) 对婴儿肠道微生物组合的影响.
- 为了确定这些由牛奶引起的微生物群变化是否会影响婴儿骨发育.
主要方法:
- 从SMM,NSM或MFM养的婴儿的便微生物群转移到无菌小鼠 (GF CTRL).
- 在35天后使用16S rRNA测序分析肠道微生物组合的分析.
- 通过微计算机断层扫描 (μCT) 分析评估骨发育.
主要成果:
- 观察到的微生物组变化:科拉 (SMM),阿克尔曼西亚 (NSM) 和鲁米诺可可科亚 (MFM) 的丰富差异.
- 骨发育分析显示,与GF CTRL相比,MFM小鼠的骨体积/骨细胞数量下降.
- 与MFM和GF CTRL相比,在SMM和NSM小鼠中观察到炎症因子 (TNF-α,IL-1β) 的增加.
结论:
- 婴儿奶粉养可能会抑制骨的生长和发育.
- 肠道微生物组合的变化与配方奶粉对骨发育的影响有关.
- 在这个模型中,人乳,无论其分泌器状态如何,都支持正常的骨发育.
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